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Ten patients with familial hypercholesterolaemia were subjected to partial ileal by-pass surgery. Plasma cholesterol fell by 41 and 38% and low-density lipoprotein cholesterol by 51 and 46% after six and 18 months respectively. High-density and very low-density lipoprotein cholesterol and plasma triglycerides were unaffected. Alanine aminotransferase increased transiently in half of the patients. Diarrhoea and slight steatorrhoea troubled most of the patients for the duration of 18 months' period of observation. Other long-term side effects were slight but significant increase in the renal excretion of oxalic acid and reduction in the intestinal absorption of calcium. The study shows that this operation has metabolic side-effects that warrant continued medical care of these patients.
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
August 1967,
Proceedings of the Royal Society of Medicine,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
February 1979,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
December 1977,
European journal of clinical investigation,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
November 1981,
Lancet (London, England),
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
November 1982,
Journal of the Royal Society of Medicine,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
January 1984,
The Netherlands journal of medicine,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
January 1982,
Lancet (London, England),
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
January 1985,
The Netherlands journal of medicine,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
October 1999,
The British journal of surgery,
O Faergeman, and
H Meinertz, and
E Hylander, and
K Fischerman, and
S Jarnum, and
O V Nielsen
October 1981,
Lancet (London, England),
