Repeat transplacental transfer of Toxoplasma gondii in dairy goats. 1982

J P Dubey

Six dogs inoculated with the GT-1 strain of Toxoplasma gondii aborted or gave birth to kids transplacentally infected with T gondii. In the next breeding season, does were bred to a T gondii-negative buck. Four of the 6 does gave birth to kids not infected with T gondii. At 139 days after breeding, 1 doe gave birth to 3 kids infected with T gondii. Kid 1 was born alive but died within 1 hour of birth; kid 2 was born dead; and kid 3 was born weak then euthanatized 1 day after birth. Toxoplasma gondii was isolated from fetal cotyledons and brain, heart, lung, liver, thigh muscle, and spinal cord of each kid. Microscopically, evidence of interstitial nodular pneumonia, hepatic necrosis, nonsuppurative myositis, myocarditis, and encephalitis was found in each kid. The 6th doe aborted 2 disintegrated fetuses at about 3 months of gestation.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D006041 Goats Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP. Capra,Capras,Goat
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014122 Toxoplasma A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man. Toxoplasma gondii,Toxoplasma gondius,Toxoplasmas,gondius, Toxoplasma
D014124 Toxoplasmosis, Animal Acquired infection of non-human animals by organisms of the genus TOXOPLASMA. Animal Toxoplasmoses,Animal Toxoplasmosis,Toxoplasmoses, Animal
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