-transparent.png){kind=logo}
L-Glutamine D-fructose-6-phosphate aminotransferase (2-amino-2-deoxy-D-glucose-6-phosphate ketol-isomerase (amino-transferring), EC 5.3.1.19) activities in the three main salivary glands of male and female mice were measured. It was found that the activity in the submandibular gland was about 10 times more in females than in males, whereas the activities in the sublingual and parotid glands of males and females were similar. The activity in the submandibular gland of female mice was not affected appreciably by ovariectomy but it decreased to the level in males on injection of testosterone. The activity in males was not affected appreciably by injection of progesterone or 17beta-estradiol, but it increased to the level in females after castration. The increased activity in castrated male mice was decreased again to the normal level by testosterone injection. Thus, this sex difference is caused by androgen, not by female hormones. On the basis of in vivo experiments using actinomycin D, it was suggested that testosterone produced an "enzyme inhibitor", which suppressed the enzyme activity in the submandibular glands of androgen-rich animals.
K Hosoi, and
S Kobayashi, and
T Ueha
January 1969,
Acta biologica Academiae Scientiarum Hungaricae,
K Hosoi, and
S Kobayashi, and
T Ueha
August 1981,
Analytical biochemistry,
K Hosoi, and
S Kobayashi, and
T Ueha
August 1974,
Biochimica et biophysica acta,
K Hosoi, and
S Kobayashi, and
T Ueha
October 1971,
Biochimica et biophysica acta,
K Hosoi, and
S Kobayashi, and
T Ueha
January 1970,
Experimental eye research,
K Hosoi, and
S Kobayashi, and
T Ueha
March 1970,
Indian journal of biochemistry,
K Hosoi, and
S Kobayashi, and
T Ueha
July 1972,
Biochimica et biophysica acta,
K Hosoi, and
S Kobayashi, and
T Ueha
January 1971,
Biochimica et biophysica acta,
K Hosoi, and
S Kobayashi, and
T Ueha
July 1975,
Journal of pharmaceutical sciences,
K Hosoi, and
S Kobayashi, and
T Ueha
April 1967,
Archives internationales de pharmacodynamie et de therapie,
