Age-related changes in tanycytes of the median eminence were observed at both the light and electron microscopic level in male and female rats at ages 4 weeks to 14 months. The most obvious changes involved a marked progressive increase in number and size of droplets identified histochemically as neutral lipid and the development of complex degenerate bodies in the perivascular contact zone. These degenerate bodies consisted of large multiple complexes of myelin figures containing intercalated channels and pools of electron-dense material. They often occurred interspersed among large lipid droplets. The degenerate bodies (myelin figure complexes) and associated lipid droplets occupied much of the contact zone in the older animals. Evidence of axonal degeneration and tanycytic phagocytosis of deteriorating neural elements was also present. These age-related changes occurred independent of sex and were not affected by gonadectomy. This tanycyte response to aging in the median eminence is very similar to the response of neurohypophysial pituicytes to axonal degeneration, suggesting a phagocytic glial role for tanycytes.