Biomaterial Database

Effects of vagal stimulation and carotid body chemoreceptor stimulating agents on phrenic nerve activity in vagotomized rabbits. 1982

S Matsumoto

Effects of vagal stimulation and carotid body chemoreceptor stimulating agents on phrenic nerve activity were studied in vagotomized rabbits. The decreases of TI and IPA were proportional to the increase of stimulus frequency and these inhibitory effects were rapidly reversed after vagal stimulation was discontinued. The continuous vagal stimulation at low frequency resulted in a marked potentiation of TI accompanied by a decrease of IPA. The prolongation of TI caused by subthreshold vagal stimulation which failed to terminate the inspiration may probably be due to the inhibition of the PC phasic activity. An intracarotid injection of NaCN led to a decrease of TI and it showed a marked potentiation of IPA. DA and 5-HT showed apneustic respiratory patterns in phrenic responses associated with a slight increase of IPA. Therefore, it may be suggested that the afferent inputs from carotid body chemoreceptor by DA and 5-HT are projected to the I beta neurons in the NTS whereas the input from NaCN-stimulated carotid body chemoreceptor is projected into the I alpha neurons.

UI	MeSH Term	Description	Entries
D010791	Phrenic Nerve	The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.	Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D011661	Pulmonary Stretch Receptors	Stretch receptors found in the bronchi and bronchioles. Pulmonary stretch receptors are sensors for a reflex which stops inspiration. In humans, the reflex is protective and is probably not activated during normal respiration.	Receptors, Pulmonary Stretch,Receptors, Stretch, Pulmonary,Stretch Receptors, Pulmonary,Lung Stretch Receptors,Receptors, Stretch, Lung,Stretch Receptors, Lung,Lung Stretch Receptor,Pulmonary Stretch Receptor,Receptor, Lung Stretch,Receptor, Pulmonary Stretch,Receptors, Lung Stretch,Stretch Receptor, Lung,Stretch Receptor, Pulmonary
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D012125	Respiratory Center	Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.	Center, Respiratory,Centers, Respiratory,Respiratory Centers
D002344	Carotid Body	A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.	Glomus Caroticum,Bodies, Carotid,Body, Carotid,Caroticum, Glomus,Carotid Bodies
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D012966	Sodium Cyanide	A highly poisonous compound that is an inhibitor of many metabolic processes and is used as a test reagent for the function of chemoreceptors. It is also used in many industrial processes.	Cyanogran,Cyanide, Sodium