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The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produced continued REM sleep suppression over several weeks. In summary, nortriptyline altered EEG sleep in a pattern similar to that of amitriptyline. REM latency and REM sleep time were consistently reduced by drug administration, while REM activity was only transiently altered as with amitriptyline. The comparison with amitriptyline showed, for the most part, similar influences on REM sleep without the sedative effects of amitriptyline.
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
April 1996,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
January 1982,
Advances in biochemical psychopharmacology,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
September 1983,
The American journal of psychiatry,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
May 1992,
Progress in neuro-psychopharmacology & biological psychiatry,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
February 1998,
Journal of clinical psychopharmacology,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
January 1991,
The Journal of neuropsychiatry and clinical neurosciences,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
January 1982,
Psychopharmacology,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
August 1992,
Journal of clinical psychopharmacology,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
May 1987,
The American journal of psychiatry,
D J Kupfer, and
D G Spiker, and
A Rossi, and
P A Coble, and
D Shaw, and
R Ulrich
March 1989,
Biological psychiatry,
