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It was shown in experiments on cats anesthesized with nembutal that sodium hydroxybutyrate given in doses of 100 and 200 mg/kg increases the coronary blood flow in the intact myocardium. At the same time oxygen consumption by the heart rises to a far less degree. The drug provokes negligible hypertension, raises the systolic and cardiac outputs, and enhances myocardial contractility. It was discovered in experiments on dogs with the ischemized heart that sodium hydroxybutyrate in a dose of 200 mg/kg increases the blood supply both to the intact and ischemized myocardium areas. Changes in myocardial ischemia duration and in the hemodynamics produced by sodium hydroxybutyrate are similar to those caused by the drug in experiments with the intact heart.
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1988,
Fiziologicheskii zhurnal,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
March 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1985,
Sovetskaia meditsina,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1988,
Farmakologiia i toksikologiia,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1979,
Farmakologiia i toksikologiia,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
May 1959,
The American journal of cardiology,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
September 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
January 1985,
Farmakologiia i toksikologiia,
G G Chichkanov, and
A K Bogolepov, and
I B Tsorin, and
D D Matsievskiĭ
November 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
