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Hypoxanthine (HX) and lactate are degradation products from energy-rich intracellular substrates (ATP and glycogen), and their concentration will increase during anaerobic conditions, such as fetal asphyxia. In this study the accumulation of the two metabolites in blood during asphyxia was studied in 7 acutely exteriorized fetal lambs. The arterio-venous difference of HX and lactate over the brain was related to the function of the fetal brain as reflected by the somato-sensory evoked electroencephalogram potentials (SEP). Increased concentrations of HX in plasma and lactate in blood occurred simultaneously with deterioration of the SEP and the 3 variables correlate highly significantly. During normoxia, a net cerebral influx was found for HX, which in combination with severe asphyxia gradually changed to a net efflux. A linear correlation was found between the cerebral arterio-venous differences of HX and the impairment of the SEP. No such correlation existed for lactate. The results suggest, that the fetal brain has a high threshold for degrading its energy-rich intracellular purines.
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
October 2007,
Journal of neurosurgical anesthesiology,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
December 1978,
Canadian journal of physiology and pharmacology,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
July 1988,
American journal of hematology,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
May 1976,
Anaesthesia and intensive care,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
May 1965,
Journal of applied physiology,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
June 2006,
Minerva anestesiologica,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
May 1972,
Acta paediatrica Scandinavica,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
January 1969,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
April 1982,
Lancet (London, England),
K Thiringer, and
S Blomstrand, and
A Hrbek, and
K Karlsson, and
I Kjellmer
September 1953,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
