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1. Angiotensin II was infused at stepwise increasing dose rates (2, 4 and 10 pmol min-1 kg-1) in 12 normal subjects. Infusions were performed in the presence of normocalcaemia, mild hypercalcemia induced by concomitant calcium gluconate infusion, and after 2 weeks of treatment with nifedipine. 2. Pre-infusion plasma levels of angiotensin II, renin or aldosterone were not altered by acute mild hypercalcaemia or administration of nifedipine. The angiotensin II-induced increases in plasma aldosterone were also similar under the three study conditions. 3. Variations in calcium metabolism occurring under clinical conditions appear to play a minor role in modulating the angiotensin II-dependent pathway of aldosterone regulation in normal man.
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M G Bianchetti, and
C Beretta-Piccoli, and
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M G Bianchetti, and
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October 1994,
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M G Bianchetti, and
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M G Bianchetti, and
C Beretta-Piccoli, and
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M G Bianchetti, and
C Beretta-Piccoli, and
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K Boehringer, and
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J J Morton
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Mayo Clinic proceedings,
M G Bianchetti, and
C Beretta-Piccoli, and
P Weidmann, and
K Boehringer, and
L Link, and
J J Morton
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Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
M G Bianchetti, and
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K Boehringer, and
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J J Morton
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