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A 32-year-old female attempted suicide by consuming large quantities of both phenytoin (P) and phenobarbital (Pb). On hospital admission, serum drug concentrations (SDC), measured by immunoassay, were 46 micrograms/ml for P and 86 micrograms/ml for Pb. The patient remained unconscious, requiring mechanical ventilation, for the next two weeks. Serial SDC demonstrated: (1) continued P absorption over the next five days; (2) different elimination patterns for the two drugs (Pb exhibited first-order elimination while P elimination represented Michaelis-Menten kinetic); and (3) the limited effectiveness of forced alkaline diuresis in lowering Pb serum concentration, though resulting in an episode of pulmonary edema. The patient's clinical status subsequently improved and correlated well with SDC decline into the usual therapeutic range.
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
April 1987,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
March 1978,
The Western journal of medicine,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
April 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
April 1994,
Journal of clinical pharmacology,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
December 1982,
Neurology,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
July 1988,
Pharmacological research communications,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
January 1989,
The American journal of emergency medicine,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
January 1983,
The Journal of emergency medicine,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
January 1997,
Heart & lung : the journal of critical care,
P H Vlasses, and
M L Rocci, and
H Koffer, and
R K Ferguson
December 1976,
Clinical chemistry,
