-transparent.png){kind=logo}
The plasma binding of diazepam was determined serially in 24 women undergoing either elective induction of labour (vaginal or emergency caesarean delivery) or elective caesarean section at term and in 5 nonpregnant women requiring abdominal surgery. In the majority of pregnant patients, a marked increase in diazepam percentage free was observed during labour or prior to caesarean section, reaching a maximum, 1.6 to 3.2 fold increase at delivery or within 4 h postpartum; by the fifth day postpartum, diazepam percentage free was lower than on admission to hospital. In contrast, little change in diazepam percentage free was observed during the perisurgical period in nonpregnant patients. In parturient and surgical patients, the time courses of diazepam percentage free and plasma nonesterified fatty acid (NEFA) concentration were parallel. Bivariate regression analyses of pooled data demonstrated a strong correlation (r = 0.642, p = less than 0.010 between diazepam percentage free and corresponding NEFA concentration and a weaker correlation between diazepam percentage free and both albumin (r = 0.319, p less than 0.02) or total protein (r = 0.438, p less than 0.01). From multiple linear regression it was demonstrated that 54% of the variability in diazepam percentage free could be attributed to plasma NEFA and albumin concentrations. NEFA displacement of plasma bound diazepam was substantiated using crystalline human serum albumin. An approximate 65% increase in plasma alpha 1 acid glycoprotein levels was observed posttrauma in both parturient and surgical patients but was unrelated to diazepam binding events. A relationship between diazepam plasma binding changes and concurrently altered disposition of diazepam during parturition is postulated.
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
November 1983,
Clinical pharmacology and therapeutics,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
December 1956,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
August 1965,
Experientia,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
May 1958,
A.M.A. archives of internal medicine,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
February 1959,
The Journal of clinical investigation,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
May 1960,
Metabolism: clinical and experimental,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
January 1974,
Physiologia Bohemoslovaca,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
January 1969,
Le Diabete,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
August 2012,
Diabetes care,
M J Ridd, and
K F Brown, and
R G Moore, and
W G McBride, and
R L Nation
April 1963,
The American journal of the medical sciences,
