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13 patients, who had been subjected to hemoperfusion with Amberlite XAD-4 resin (Haemoresin, Fa. Braun), because of acute intoxications, were examined for the adsorption of bioactive material from the blood. A mean treatment period of four hours at a blood flow rate of 200 ml/min. resulted in a marked thrombocyte decrease by 43% and changes in the concentrations of proteins, complement components C3 and C4 (16-26%) triglycerides (33%), aldosterone (33%) and testosterone (20%). Low molecular weight substances and electrolytes, however, were only slightly or not affected. Thus hemoperfusion system with its poor biocompatibility and inability to remove BUN, electrolytes and water is only suitable for short-term treatment and cannot be used without detailed control of possible side effects and perhaps substitution for treatment of chronic renal or hepatic failure. Hemoperfusion has proved an efficient method of treating various exogenous intoxications. The adsorption of biologically active material from the blood constitutes several side effects which contraindicate long-term treatment, above all of endogenous intoxications such as chronic renal failure and hepatic failure. With the type of adsorber used - various charcoal preparations, resins etc. such as uncoated material or coated with different substances - these side effects vary and have not yet been investigated in a systematic, comparative and comprehensive way. The present investigations are meant to check the adsorption behaviour of Amberlite XAD-4 Resin in vivo towards some selected blood constituents and the influence of hemoperfusion on the concentrations.
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
January 1983,
Kidney international,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
October 1981,
La Revue de medecine interne,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
November 1982,
Journal of toxicology. Clinical toxicology,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
January 1982,
Transactions - American Society for Artificial Internal Organs,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
September 1979,
Archives of toxicology,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
May 1979,
Artificial organs,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
October 1980,
Clinical toxicology,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
March 1995,
Casopis lekaru ceskych,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
May 1982,
Artificial organs,
G Stein, and
H Sperschneider, and
A Börner, and
A Stelzner, and
K Günther, and
R Fünfstück, and
E Keil, and
H Lauterbach
January 1977,
Clinical toxicology,
