Biomaterial Database

Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans. 1982

P A Farrell, and W K Gates, and M G Maksud, and W P Morgan

Six well-trained endurance athletes were studied to determine if submaximal treadmill exercise results in increased plasma levels of beta-endorphin/beta-lipotropin (Bh-Ep/Bh-LPH) immunoreactivity. Bh-Ep/Bh-LPH immunoreactivity was measured by radio immunoassay in plasma from six experienced runners before and after 30-min treadmill runs at a self-selected pace, 60 and 80% VO2 max, and a control experiment of 30 min rest. All tests were randomized and occurred during the same time of day for a given subject (0600--1500 h). Preexercise Bh-Ep/Bh-LPH values averaged between 10 and 20 pg/ml and increased two- to fivefold after each run. The increase was statistically significant (P less than 0.05) only after the 60% run when Bh-Ep/Bh-LPH increased to a mean of 58.3 pg/ml. A large individual variation in the Bh-Ep/Bh-LPH response to running was noted. Mood state and perceptual data were also collected, and no significant relationship with Bh-Ep/Bh-LPH was evident. These data suggest that the stress of treadmill running acts as a stimulus to greater Bh-Ep/Bh-LPH secretion, a reduction in its degradation, or a combination of these, which leads to increased levels of these ligands in venous blood. The physiological significance of these increased plasma levels is not clear.

UI	MeSH Term	Description	Entries
D007590	Jogging	Running at a low rate of speed. It can be done as a means of conditioning or for general health and well being.	Joggings
D008083	beta-Lipotropin	A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.	Lipotropin,Adipozin,beta-LPH,beta-Lipotrophin,beta LPH,beta Lipotrophin,beta Lipotropin
D008297	Male		Males
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D010807	Physical Endurance	The time span between the beginning of physical activity by an individual and the termination because of exhaustion.	Endurance, Physical,Physical Stamina,Stamina, Physical
D011863	Radioimmunoassay	Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.	Radioimmunoassays
D004723	Endorphins	One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.	Endorphin
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005260	Female		Females
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse