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The binding of [3H]spiperone, a neuroleptic/dopamine receptor ligand, to membranes of the ventral tegmental area of the rat was studied in vitro and found to be rapid, saturable, reversible, and of high affinity. Specific binding was displaced by the dopaminergic agonists dopamine, apomorphine, and 2-amino-6,7-dihydroxytetralin, and stereospecifically by the neuroleptic drugs butaclamol and flupenthixol. Bromocryptine and other ergots displaced the binding, as did the D-2 antagonists domperidone, molindone, metoclopramide, and sulpiride. Noradrenergic, histaminergic, and serotonergic components of the binding were not detected in displacement studies with various agonists and antagonists. These data are consistent with the hypothesis that [3H]spiperone labels dopamine receptors in the ventral tegmental area that are not linked to adenylate cyclase and are therefore likely to be of the D-2 type.
A L Gundlach, and
D McDonald, and
P M Beart
January 1991,
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A L Gundlach, and
D McDonald, and
P M Beart
June 1979,
Brain research,
A L Gundlach, and
D McDonald, and
P M Beart
July 1979,
European journal of pharmacology,
A L Gundlach, and
D McDonald, and
P M Beart
January 1997,
Polish journal of pharmacology,
A L Gundlach, and
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P M Beart
March 1997,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
A L Gundlach, and
D McDonald, and
P M Beart
July 1979,
Bollettino della Societa italiana di biologia sperimentale,
A L Gundlach, and
D McDonald, and
P M Beart
January 2023,
Biological psychiatry global open science,
A L Gundlach, and
D McDonald, and
P M Beart
May 2009,
Behavioural brain research,
A L Gundlach, and
D McDonald, and
P M Beart
December 1977,
European journal of pharmacology,
A L Gundlach, and
D McDonald, and
P M Beart
April 1989,
Activitas nervosa superior,
