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The decrease in plasma pyruvate kinase activity after administration of various tocopherols to vitamin E-deficient rats provided the basis for a 3-point parallel-slope assay for vitamin E activity. Based on 6 replicate assays, RRR-alpha-tocopheryl acetate (RRR-alpha-TA) was 141% as active as all-rac-alpha-tocopheryl acetate (all-rac-alpha-TA). This confirms many previous reports with other bioassays and is in agreement with the unit-weight relationships assigned by The National Formulary. 2-ambo-alpha-Tocopheryl acetate was 97% as active as all-rac-alpha-TA indicating that only the configuration of the 2-position on the chromanol ring is important in determining the biological activity of alpha-tocopherol.
L J Machlin, and
E Gabriel, and
M Brin
January 1990,
Free radical research communications,
L J Machlin, and
E Gabriel, and
M Brin
September 1986,
FEBS letters,
L J Machlin, and
E Gabriel, and
M Brin
July 1990,
FEBS letters,
L J Machlin, and
E Gabriel, and
M Brin
January 1983,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
L J Machlin, and
E Gabriel, and
M Brin
December 1974,
Antimicrobial agents and chemotherapy,
L J Machlin, and
E Gabriel, and
M Brin
July 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L J Machlin, and
E Gabriel, and
M Brin
June 1975,
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
L J Machlin, and
E Gabriel, and
M Brin
January 1974,
The Journal of nutrition,
L J Machlin, and
E Gabriel, and
M Brin
June 1982,
The Journal of nutrition,
L J Machlin, and
E Gabriel, and
M Brin
July 1982,
Endocrinology,
