BIOMAT Database Logo BIOMAT Database Logo

Lipophilin-induced experimental allergic encephalomyelitis in guinea pigs. 1982

R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood

Clinical signs of EAE were infrequently observed (1/20) in adult Hartley guinea pigs challenged with isolated human myelin lipophilin in complete Freund's adjuvant. However, CNS vasculitis and parenchymal infiltration by inflammatory cells were found in 10 of 20 inoculated animals. Localized, nonconfluent, small demyelinated lesions were detected in the brain and spinal cord of 5/20 Hartley guinea pigs during an observation period of 120 days. The frequency of both inflammatory and demyelinated lesions in Hartley animals appeared to be dose-dependent, but extensive demyelinated lesions were not induced. Persistent residual inoculation mixture at the site of injection was found in animals showing CNS inflammatory and/or demyelinated lesions. In contrast to the Hartley strain, young strain 13 guinea pigs were clinically and pathologically unresponsive to challenge with lipophilin and mycobacteria in water-in-oil emulsion.

UI MeSH Term Description Entries
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009185 Myelin Proteins MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure. Myelin Protein,Protein, Myelin,Proteins, Myelin
D011510 Proteolipids Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004681 Encephalomyelitis, Autoimmune, Experimental An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5) Autoimmune Encephalomyelitis, Experimental,Encephalomyelitis, Allergic,Encephalomyelitis, Experimental Autoimmune,Allergic Encephalomyelitis,Allergic Encephalomyelitis, Experimental,Autoimmune Experimental Encephalomyelitis,Experimental Allergic Encephalomyelitis,Experimental Autoimmune Encephalomyelitis,Encephalomyelitis, Autoimmune Experimental,Encephalomyelitis, Experimental Allergic,Experimental Allergic Encephalomyelitides,Experimental Encephalomyelitis, Autoimmune
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea

Related Publications

R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Myelin lipophilin-induced experimental allergic encephalomyelitis in guinea pigs.
January 1980, Progress in clinical and biological research,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein.
January 1985, Journal of the neurological sciences,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Prevention of experimental allergic encephalomyelitis in guinea pigs.
April 1949, Journal of neuropathology and experimental neurology,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Prevention of experimental allergic encephalomyelitis in guinea pigs.
January 1949, Journal of neuropathology and experimental neurology,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
[Experimental allergic encephalomyelitis in guinea pigs caused by meningococci].
October 1981, Zhurnal mikrobiologii, epidemiologii i immunobiologii,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Cyclophosphamide inhibition of experimental allergic encephalomyelitis in guinea pigs.
November 1969, Archives internationales de pharmacodynamie et de therapie,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
[Lymphocyte blast transformation in guinea pigs with experimental allergic encephalomyelitis].
February 1975, Biulleten' eksperimental'noi biologii i meditsiny,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs.
January 1980, Neurochemical research,
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
IMMUNO-CONGLUTININ LEVEL IN GUINEA PIGS WITH EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS.
October 1963, Life sciences (1962),
R E Madrid, and H M Wisniewski, and G A Hashim, and M A Moscarello, and D D Wood
Thymectomy and chronic relapsing experimental allergic encephalomyelitis in guinea pigs.
November 1984, Archives of neurology,
Copied contents to your clipboard!