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To study the action of corticosteroids on erythroid precursors, (burst forming unit-erythroid and colony forming unit-erythroid) in Diamond-Blackfan Syndrome (DBS), marrow from a newly diagnosed untreated infant was studied in vitro with prednisone and dexamethasone. This patient subsequently proved to be steroid responsive. Colony numbers increased linearly in an erythropoietin (EPO) dose response study. There was marked enhancement of colony numbers at all EPO doses after adding either prednisone (10(-6) M) or dexamethasone (10(-9) M) to the cultures. The data indicate that corticosteroids augment erythropoiesis at both early (BFU-E) and late (CFU-E) stages of development in DBS. In contrast, marrow from a second infant with DBS, clinically steroid resistant, failed to respond to steroids in vitro.
H S Chan, and
E F Saunders, and
M H Freedman
September 1976,
Science (New York, N.Y.),
H S Chan, and
E F Saunders, and
M H Freedman
September 2010,
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine,
H S Chan, and
E F Saunders, and
M H Freedman
April 2007,
Blood,
H S Chan, and
E F Saunders, and
M H Freedman
October 2009,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
H S Chan, and
E F Saunders, and
M H Freedman
January 1996,
Haematologica,
H S Chan, and
E F Saunders, and
M H Freedman
October 2020,
Science translational medicine,
H S Chan, and
E F Saunders, and
M H Freedman
January 2001,
Ryoikibetsu shokogun shirizu,
H S Chan, and
E F Saunders, and
M H Freedman
April 1989,
Blood,
H S Chan, and
E F Saunders, and
M H Freedman
January 1970,
Przeglad lekarski,
H S Chan, and
E F Saunders, and
M H Freedman
January 1978,
Blood cells,
