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The course of the degradation of tropicamide solutions was elucidated. Thus, inter alia, intramolecular elimination of water leads to a compound comparable to apoatropine that the authors designated by atropicamide. Furthermore, methods are described that permit (after thin-layer chromatographic repartition) to detect and to determine quantitatively the active principle in the presence of its degradation products. Tropicamide is stable in aqueous solution; eye-drops prepared from such a solution (Mydrum) are stable for no less than 5 years.
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