-transparent.png){kind=logo}
1. Hepatic elimination of renin was measured in 10 well-compensated cardiac patients with normal liver function during a control period and during a period of reduced hepatic plasma flow, induced by physical exercise (seven patients) or intravenous infusion of lysine vasopressin (three patients). 2. Hepatic renin elimination rate (hepatic plasma flow x arterial-hepatic vein difference of plasma renin activity) was found to be linearly correlated with arterial plasma renin activity (r = 0.986, P less than 0.001). 3. When hepatic plasma flow fell by 45% the hepatic extraction ratio of renin (arterial-hepatic vein plasma renin activity difference/arterial plasma renin activity) increased by 75%. Hepatic renin clearance (hepatic plasma flow x extraction ratio) remained constant. 4. The results indicate that changes in the hepatic elimination rate of renin do not contribute to changes in plasma renin activity during these events.
B Hesse, and
E D Andersen, and
H Ring-Larsen
January 1968,
Enzymologia biologica et clinica,
B Hesse, and
E D Andersen, and
H Ring-Larsen
January 1987,
European journal of clinical pharmacology,
B Hesse, and
E D Andersen, and
H Ring-Larsen
October 1979,
European journal of clinical investigation,
B Hesse, and
E D Andersen, and
H Ring-Larsen
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
B Hesse, and
E D Andersen, and
H Ring-Larsen
December 1969,
Clinical science,
B Hesse, and
E D Andersen, and
H Ring-Larsen
March 1993,
Clinical and experimental hypertension (New York, N.Y. : 1993),
B Hesse, and
E D Andersen, and
H Ring-Larsen
January 1973,
Clinical pharmacology and therapeutics,
B Hesse, and
E D Andersen, and
H Ring-Larsen
September 1972,
The Journal of clinical endocrinology and metabolism,
B Hesse, and
E D Andersen, and
H Ring-Larsen
October 1938,
The Biochemical journal,
B Hesse, and
E D Andersen, and
H Ring-Larsen
January 1965,
Transactions of the Association of American Physicians,
