Biomaterial Database

Contact allergy to toothpaste flavors. 1978

K E Andersen

Toothpaste flavors are fragrance mixtures. Oil of peppermint and spearmint, carvone and anethole are ingredients with a low sensitizing potential, but they are used in almost every brand of toothpaste and caused seven cases of contact allergy in a 6-year period at Gentofte Hospital. Toothpaste reactions are rare due to several reasons; local factors in the mouth, the low sensitizing potential of the flavors generally used, and the lack of recognition. It is emphasized that the toothpaste battery for patch testing has to be relevant and changed according to the consumers' and manufacturers' taste and fashion.

UI	MeSH Term	Description	Entries
D007659	Ketones	Organic compounds containing a carbonyl group	Ketone
D009059	Mouth Diseases	Diseases involving the MOUTH.	Disease, Mouth,Diseases, Mouth,Mouth Disease
D010328	Patch Tests	Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.	Patch Testing,Patch Test,Patch Testings,Test, Patch,Testing, Patch,Testings, Patch,Tests, Patch
D003718	Denmark	A country in northern Europe, bordering the Baltic Sea and the North Sea. The capital is Copenhagen.	Faeroe Islands,Faroe Islands
D003802	Dentifrices	Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.	Polishes, Dental,Dental Polishes,Dentifrice
D003877	Dermatitis, Contact	A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	Contact Dermatitis,Dermatitis Venenata,Eczema, Contact,Hypersensitivity, Contact,Sensitivity, Contact,Contact Dermatitides,Contact Eczema,Contact Hypersensitivities,Contact Hypersensitivity,Contact Sensitivities,Contact Sensitivity,Dermatitides, Contact,Hypersensitivities, Contact,Sensitivities, Contact
D005421	Flavoring Agents	Substances added to foods and medicine to improve the taste.	Flavor Additives,Flavor Enhancers,Additive, Flavor,Additives, Flavor,Agent, Flavoring,Agents, Flavoring,Enhancer, Flavor,Enhancers, Flavor,Flavor Additive,Flavor Enhancer,Flavoring Agent
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000781	Anethole Trithione	Choleretic used to allay dry mouth and constipation due to tranquilizers.	Anetholtrithion,Trithioanethol,Trithioparamethoxyphenylpropene,Anethol Dithiolthione,Anetholetrithione,Anetholtrithione,Anisyldithiolthionine,Felviten,Heporal,Mucinol,SL-25,Sialor,Sonicur,Sulfarlem,Sulfralem,Tiotrifar,Trithio,Dithiolthione, Anethol,SL 25,Trithione, Anethole
D014100	Toothpastes	Dentifrices that are formulated into a paste form. They typically contain abrasives, HUMECTANTS; DETERGENTS; FLAVORING AGENTS; and CARIOSTATIC AGENTS.	Toothpaste