Effects of ethanol on locomotor activity in rats of different ages. 1982

R Lamble, and U Rydberg

Using male Sprague-Dawley rats of different ages, simple motor activity was measured over three 4 min. runs in a square open field after ethanol (EtOH, 2 g/kg, intraperitoneally) or saline. The different groups consisted of 12 animals whose mean ages was 20, 40 and 60 days. Motor activity and blood ethanol levels were measured at 30, 60 and 120 min. after injection. Blood ethanol levels (measured after each run) decreased from 1st to 3rd run in 20 and 40 day groups and increased from 1st to 2nd run in the 60 day group, before decreasing. Activity data indicated: 1) decrease in motor activity the 3 runs by all saline and the 21 day EtOH groups, 2) initial lower activity induced by EtOH in all age groups, 3) lack of decrease in activity over 3 runs in 40 and 60 day EtOH groups. All saline and EtOH age groups showed within-run decrease of activity.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D006185 Habituation, Psychophysiologic The disappearance of responsiveness to a repeated stimulation. It does not include drug habituation. Habituation (Psychophysiology),Habituation, Psychophysiological,Psychophysiologic Habituation,Psychophysiological Habituation,Habituations (Psychophysiology)
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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