Biomaterial Database

Disulfiram acceptors and refusers: do they differ? 1982

P M O'Neil, and J C Roitzsch, and J P Giacinto, and W C Miller

The present study examined possible personality and mood state correlates of alcoholics' decisions to accept or refuse disulfiram (Antabuse) as past of their treatment program. Subjects were 104 male veterans in an inpatient alcohol treatment program who were offered disulfiram after detoxification and evaluation. All subjects completed the Minnesota Multiphasic Personality Inventory, the Profile of Mood States, and the State-Trait Anxiety Inventory. Subjects were classified as acceptors (n = 78) or refusers (n = 26) based on their response to staff encouragement to undergo a trial of disulfiram. There were no significant group differences on age, racial composition, or any of the personality or mood state measures, with the exception of a trend (p less than .06) for acceptors to score higher than refusers on the masculinity-femininity scale of the MMPI. Examinations of distributions of MMPI profile code types similarly showed no differences between the two groups. Possible contextual explanations of these results are examined. Findings offer no support for the assumption that agreement to take disulfiram signifies greater motivation or intention to remain abstinent.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008950	MMPI	A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.	Minnesota Multiphasic Personality Inventory
D009042	Motivation	Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.	Incentives,Disincentives,Expectations,Disincentive,Expectation,Incentive,Motivations
D010349	Patient Compliance	Voluntary cooperation of the patient in following a prescribed regimen.	Client Adherence,Client Compliance,Non-Adherent Patient,Patient Adherence,Patient Cooperation,Patient Noncompliance,Patient Non-Adherence,Patient Non-Compliance,Patient Nonadherence,Therapeutic Compliance,Treatment Compliance,Adherence, Client,Adherence, Patient,Client Compliances,Compliance, Client,Compliance, Patient,Compliance, Therapeutic,Compliance, Treatment,Cooperation, Patient,Non Adherent Patient,Non-Adherence, Patient,Non-Adherent Patients,Non-Compliance, Patient,Nonadherence, Patient,Noncompliance, Patient,Patient Non Adherence,Patient Non Compliance,Patient, Non-Adherent,Therapeutic Compliances,Treatment Compliances
D004221	Disulfiram	A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.	Tetraethylthiuram Disulfide,Alcophobin,Antabus,Antabuse,Anticol,Bis(diethylthiocarbamoyl) Disulfide,Dicupral,Esperal,Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2,Teturam,Disulfide, Tetraethylthiuram
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000437	Alcoholism	A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol