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Diffuse esophageal spasm is a disease of unknown etiology in which neural or muscular control mechanisms malfunction, resulting in impaired and sometimes painful swallowing response, and inappropriate muscular contraction. An association between social stresses and disease activity suggesting elements of central control has been observed. In an effort to uncouple conscious central mechanisms from end organ response, we manometrically studied esophageal activity of four patients with symptomatic diffuse esophageal spasm while asleep (identified by electroencephalographic monitoring) as compared to wakeful states. We observed significant decreases from awake studies in number and duration of spontaneous contraction, during all sleep stages. We conclude that CNS mechanisms participate in the expression of the abnormal excitability of the esophagus in symptomatic diffuse esophageal spasm.
I Danielides, and
G Van Devender, and
M Anch
November 1987,
Revista espanola de las enfermedades del aparato digestivo,
I Danielides, and
G Van Devender, and
M Anch
February 1982,
Southern medical journal,
I Danielides, and
G Van Devender, and
M Anch
January 1974,
Gastroenterology,
I Danielides, and
G Van Devender, and
M Anch
August 2012,
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,
I Danielides, and
G Van Devender, and
M Anch
December 1984,
Revista espanola de las enfermedades del aparato digestivo,
I Danielides, and
G Van Devender, and
M Anch
July 2003,
Digestive diseases and sciences,
I Danielides, and
G Van Devender, and
M Anch
July 1992,
Digestive diseases and sciences,
I Danielides, and
G Van Devender, and
M Anch
February 1977,
New York state journal of medicine,
I Danielides, and
G Van Devender, and
M Anch
March 1967,
Gastroenterology,
I Danielides, and
G Van Devender, and
M Anch
August 1983,
The Surgical clinics of North America,
