Biomaterial Database

Partial inhibition of cell-mediated immunity (CMI) by niridazole: effect upon development of autoimmune aspermatogenic orchitis (AIAO) in guinea pigs. 1982

M S Nemirovsky

The effects of Niridazole upon the development of autoimmune aspermatogenic orchitis (AIAO) was studied in guinea pigs. Niridazole administration before, during, or three days after alloimmunization with sperm cells emulsified in Freund's complete adjuvant (FCA) produced slight changes in some correlates of cell-mediated immunity. No significant changes in humoral immunity or testicular histopathology can be observed at these periods. When Niridazole was administered ten days after alloimmunization, a significant inhibition of all manifestations of cell-mediated immunity against spermatozoa was observed. Thirty days after alloimmunization, half of the animals studied failed to develop significant histopathological changes in testis or epididymis. However, the titer of cytotoxic antibodies to testicular cells increased from threefold to fourfold, when compared to those of alloimmunized animals not receiving Niridazole. The critical period for cell interactions concerned with the full expression of AIAO was found to be between ten and fifteen days after alloimmunization.

UI	MeSH Term	Description	Entries
D007111	Immunity, Cellular	Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.	Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D008297	Male		Males
D009560	Niridazole	An antischistosomal agent that has become obsolete.	Ambilar,Ambilhar,CIBA 32.644 BA,BA, CIBA 32.644
D009920	Orchitis	Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.	Orchitides
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D013091	Spermatogenesis	The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.	Spermatocytogenesis,Spermiogenesis
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor