-transparent.png){kind=logo}
1 The effect of lipid peroxidation on p-aminohippurate transport by rat kidney slices was examined. 2 Ascorbic acid and Fe2+ promoted lipid peroxidation of rat renal cortical slices in a dose-related manner. 3 Ascorbic acid (1.0 mM) and Fe2+ (0.4 mM) increased tissue water and decreased the accumulation of p-aminohippurate. 4 The addition of N,N'-diphenyl-p-phenylenediamine (antioxidant), at a concentration of 1 x 10(-6) M, completely inhibited the peroxidation and recovered the accumulation of p-aminohippurate. 5 The apparent Km of p-aminohippurate uptake was increased by ascorbic acid and Fe2+ with no change in the apparent V. 6 These data suggest that ascorbic acid and Fe2+ can cause a significant alteration in p-aminohippurate and water transport of renal cortical slices and that these effects can be correlated with lipid peroxidation.
Y Fujimoto, and
T Fujita
June 1981,
Japanese journal of pharmacology,
Y Fujimoto, and
T Fujita
October 1983,
Journal of pharmacobio-dynamics,
Y Fujimoto, and
T Fujita
September 1983,
Journal of pharmacobio-dynamics,
Y Fujimoto, and
T Fujita
January 1981,
Renal physiology,
Y Fujimoto, and
T Fujita
January 1982,
Renal physiology,
Y Fujimoto, and
T Fujita
July 1977,
The Journal of endocrinology,
Y Fujimoto, and
T Fujita
April 1977,
The Journal of pharmacology and experimental therapeutics,
Y Fujimoto, and
T Fujita
July 1979,
Archives internationales de pharmacodynamie et de therapie,
Y Fujimoto, and
T Fujita
March 1981,
Journal of pharmacobio-dynamics,
Y Fujimoto, and
T Fujita
January 1959,
The American journal of physiology,
