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In this paper we have determined the long-lasting consequences of caudate and frontal cortical lesions on spontaneous neuronal firing. Lesions were made both in neonatal and adult cats. All recordings were made in adults. Qualitatively, the effects of the caudate ablations were similar whether they had been carried out in kittens or in adult cats. Caudate lesions produced long-lasting (greater than or equal to 1 year) decreases in the spontaneous firing of cortical neurons. These changes were more pronounced when made in neonates than in adults. The distributions of mean interspike intervals were also altered by these caudate lesions in the pallidum and in the ventral lateral nucleus of the thalamus. Again these effects were more marked if the animals were lesioned as neonates than as adults. Frontal cortical lesions inflicted upon adult cats produced more widespread changes in spontaneous firing rates than similar lesions made in neonates. In both groups frontal lesions slowed spontaneous firing and changed the distributions of mean interspike intervals of caudate neurons. These effects were long-lasting (greater than or equal to 1 year in neonatally-ablated animals). Cortical lesions made in adult cats markedly altered thalamic and pallidal spontaneous activity. Similar lesions made in neonates produced relatively small changes in thalamic and pallidal activity.
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
March 1979,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
February 1979,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
May 1980,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
February 1979,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
September 1978,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
June 1984,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
September 1978,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
September 1976,
Experimental neurology,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
September 2000,
Acta oto-laryngologica,
M S Levine, and
C D Hull, and
J R Villablanca, and
N A Buchwald, and
E Garcia-Rill
January 1975,
UCLA forum in medical sciences,
