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Gamma-Vinyl GABA, an irreversible inhibitor of GABA-transaminase, was administered orally in two daily doses of 250 mg to 10 patients with cerebellar ataxia (9 with Friedreich's ataxia, one with olivo-ponto-cerebellar atrophy) for at least one month in an open study. No significant difference occurred in the disability scores of cerebellar symptomatology for the group as a whole, but seven patients showed some improvement in scores with treatment and two patients claimed marked subjective amelioration. Tolerance to Gamma-Vinyl-GABA treatment was excellent. These preliminary results suggest that further studies with well-tolerated agents which enhance CNS GABA-ergic function are warranted in patients with cerebellar ataxia.
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
January 1985,
General pharmacology,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
April 1983,
Psychiatry research,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
November 1986,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
September 1981,
The New England journal of medicine,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
April 1981,
Neuropharmacology,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
May 2022,
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
March 1984,
Lancet (London, England),
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
December 1985,
Neurology,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
January 1984,
Neurology,
Y De Smet, and
J Y Mear, and
G Tell, and
P H Schechter, and
F Lhermitte, and
Y Agid
June 2009,
Atencion primaria,
