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Epilepic anormaly strain of mice "El" derived from National Institute of Health, Japan were bred by sister-brother mating during the first 3 months and maintained thereafter by random mating at this laboratory. About 20% (21/101) of virgin females and 4% (2/49) of males were infertile and rate of delivering was relatively poor; mean delivery rate was 70.6%. Delivery rate were drawn after fourth litter. The mean litter size and weaning rate were 7.54 and 97.9%, respectively. Male El mice died following convulsion. Autopsy revealed the obstruction of urether, bleeding in the bladder and seminal vesicules. The time of 50% death was 166 days of age.
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