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Sodium-lithium counter-transport in human red blood cells may be a potentially useful measurement in studies of hypertension. A kinetic expression describing this counter-transport was derived and evaluated using red cells from nine subjects at various concentrations of intracellular and extracellular Li+ and Na+. The countertransport is dependent upon all four concentrations, intracellular Li+ and Na+ as well as extracellular Li+ and Na+. We confirm that the maximum Na+-Li+ counter-transport (Vmax) is a property of the individual cells while the half-maximal saturating concentrations (K 1/2) for Li+ and Na+ are the same for all subjects. This expression permits a more thorough understanding of conditions affecting Na+-Li+ countertransport measurement.
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
October 1983,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
May 1985,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
May 1983,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
October 1990,
BMJ (Clinical research ed.),
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
September 1989,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
July 1982,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
January 1987,
Nephron,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
January 1986,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
April 1980,
The New England journal of medicine,
J B Smith, and
K O Ash, and
W M Hentschel, and
R R Williams
February 1984,
Journal of endocrinological investigation,
