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False-positive stool occult blood tests caused by iron preparations. A controlled study and review of literature. 1982

L J Lifton, and J Kreiser

Stools from 10 male volunteers were tested by Hemoccult and Hematest occult blood methods after the ingestion of ferrous sulfate and ferrous gluconate. The volunteers served as their own controls. The Hemoccult methods had 65% and 50% false-positive reactions while the Hematest had 25% and 65% false-positive reactions after ferrous sulfate and ferrous gluconate, respectively. In vitro testing confirmed that ferrous compounds caused a false-positive Hemoccult slide reaction. Previous studies of the effect of medicinal iron on occult blood tests are reviewed.

UI MeSH Term Description Entries
D007501 Iron A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Iron-56,Iron 56
D008297 Male Males
D009780 Occult Blood Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood. Fecal Occult Blood Test,Blood, Occult
D005189 False Positive Reactions Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Positive Reaction,Positive Reaction, False,Positive Reactions, False,Reaction, False Positive,Reactions, False Positive
D005243 Feces Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D005296 Ferrous Compounds Inorganic or organic compounds that contain divalent iron. Compounds, Ferrous
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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