Biomaterial Database

Effect of smoking on phenylbutazone disposition. 1982

S K Garg, and T N Ravi Kiran

A single oral dose of 6 mg phenylbutazone/kg body wt. was administered to seven cigarette smokers and to seven healthy male volunteers serving as control. Plasma phenylbutazone half-life (t1/2 beta) was shortened significantly (p less than 0.05) in the cigarette smokers as compared to the non-smoker control group. Phenylbutazone was cleared from the blood significantly faster (p less than 0.06) in the smoking group than in the non-smoking group.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D010653	Phenylbutazone	A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.	Diphenylbutazone,Fenilbutazon,Butacote,Butadion,Butadione,Butapirazol,Butapyrazole,Butazolidin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012907	Smoking	Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand.	Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits