[Experimental study of renal and uterine blood flow regulation in obstetric hypovolemic shock (author's transl)]. 1982

Y Sanda

Dynamics of the renal and uterine circulation in response to the hypovolemic shock were studied in anesthetized pregnant and nonpregnant dogs. The renal arterial blood flow (RABF), uterine arterial blood flow (UABF) and mean arterial blood pressure (MAP) were electronically integrated and recorded during the removal of 500 ml blood at the rate of 3 ml per minute. In nonpregnant bitches, there was a pronounced decrease in RABF after the 300 ml blood removal, and it became 85.2 per cent from the control level at the time of 500 ml blood removal (MAP 34.6 mmHg). In pregnant bitches however, the rapid decrease in UABF was invoked after the 200 ml blood removal, reaching 85.3 per cent decrease from the control level at the time of 500 ml blood removal (MAP 59.8 mmHg), while the decrease in RBF was attenuated in comparison with the nonpregnant animals. The decrease in UBF in pregnant animal was associated with remarkable increase in uterine vascular resistance. This implies that the hypovolemic shock generates a lending and borrowing phenomenon between the renal and uterine circulation in pregnant subject. As evidenced by the enhanced vasoconstrive responses of uterine vascular bed to injected norepinephrine (50 microgram) during the hypovolemic shock in pregnant animals, the activation on alpha receptors in the uterine vascular bed is the main cause of the phenomenon.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012079 Renal Circulation The circulation of the BLOOD through the vessels of the KIDNEY. Kidney Circulation,Renal Blood Flow,Circulation, Kidney,Circulation, Renal,Blood Flow, Renal,Flow, Renal Blood
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001810 Blood Volume Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME. Blood Volumes,Volume, Blood,Volumes, Blood
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012769 Shock A pathological condition manifested by failure to perfuse or oxygenate vital organs. Circulatory Collapse,Circulatory Failure,Hypovolemic Shock,Collapse, Circulatory,Failure, Circulatory,Shock, Hypovolemic
D014599 Uterus The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES. Fundus Uteri,Uteri,Uterine Cornua,Uterine Fundus,Uterus Cornua,Womb,Cornua, Uterine,Fundus Uterus,Fundus, Uterine,Uteri, Fundus,Wombs

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