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The lack of effective therapy of sickle cell anemia has prompted investigation of a large number of antisickling agents. The most promising drug, cyanate, was found in previous studies to be toxic when given systemically. The present study examined a semiautomated system for extracorporeal treatment with cyanate of the blood of four patients with sickle cell anemia. All patients achieved hemoglobin carbamylation levels greater than 1 mode of cyanate per mode of Hb4, with minimal systemic exposure to cyanate and no serious toxicity. Hematologic response occurred in two patients and possibly a third. Further study will be required to determine the efficacy of continuous extracorporeal carbamylation in the treatment of sickle cell anemia.
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
June 1978,
The Journal of laboratory and clinical medicine,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
January 1980,
Texas reports on biology and medicine,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
September 1976,
The Journal of clinical investigation,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
January 1984,
Haematologica,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
January 1956,
The Medical annals of the District of Columbia,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
September 1982,
The Journal of laboratory and clinical medicine,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
July 1960,
American journal of diseases of children (1960),
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
April 1959,
A.M.A. journal of diseases of children,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
February 1977,
Journal of the National Medical Association,
S P Balcerzak, and
M R Grever, and
D E Sing, and
J N Bishop, and
M L Segal
November 1954,
Circulation,
