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Three commercially available radioimmunoassays for the determination of bile acids in serum were evaluated with respect to specificity and precision. The SLCG-radioimmunoassay (Abbott) measures chiefly cholic acid conjugates, and the CBA-radioimmunoassay (Becton-Dickinson) measures all conjugated bile acids, with an over-response to taurine metabolites. With respect to cross reactions, the performances of the CG-and the CBA-radioimmunoassays differed significantly from those stated by the manufacturers, the former showing a 32% response to taurocholic acid, the latter responding only 118% to taurochenodeoxycholic acid. At physiological concentrations of albumin + globulin, the recovery of defined cholanic acids was 85-101%. Good reproducibility was shown by the CG-radioimmunoassay in the range 0.5-10.0 mumol/l, by the CBA-radioimmunoassay in the range 1.0-25.0 mumol/l, and by the SLCG-radioimmunoassay in the range 0.5-3.0 mumol/l. There were no important differences in the inter-and intra-assay precision of the three methods.
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
March 1978,
Zeitschrift fur Gastroenterologie,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
September 1981,
Rinsho byori. The Japanese journal of clinical pathology,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
February 1977,
Clinica chimica acta; international journal of clinical chemistry,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
March 1977,
Clinica chimica acta; international journal of clinical chemistry,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
October 1978,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
April 1979,
Medicina clinica,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
January 1975,
Postepy biochemii,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
November 1988,
Acta endocrinologica,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
October 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
H J Wildgrube, and
W Schiller, and
M Winkler, and
J Weber, and
H Campana, and
G Mauritz
January 1980,
Klinische Wochenschrift,
