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The response of the plasma dopamine (DA) metabolite, homovanillic acid (HVA), to two DA agonists was investigated in the rat. Apomorphine administered i.p. (2 mg/kg) produced, within one hour, a significant decrease in plasma HVA. The response of plasma HVA to apomorphine was also investigated after pretreatment with debrisoquin, a drug which selectively blocks peripheral HVA production by inhibition of MAO. Pretreatment with debrisoquin did not significantly alter the decrement in plasma HVA produced by apomorphine indicating that a substantial portion of the plasma HVA response to apomorphine is due to the drug's action on brain. Bromocriptine (2 mg/kg) was also found to produce a significant decrease in plasma HVA. Since the response of brain HVA to DA agonists reflects the sensitivity of the DA receptor, the plasma HVA response to DA agonists might be a practical method of assessing brain DA receptor sensitivity in humans.
K S Kendler, and
G R Heninger, and
R H Roth
October 1982,
Psychopharmacology bulletin,
K S Kendler, and
G R Heninger, and
R H Roth
September 2000,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
K S Kendler, and
G R Heninger, and
R H Roth
January 1984,
Comparative biochemistry and physiology. B, Comparative biochemistry,
K S Kendler, and
G R Heninger, and
R H Roth
September 1982,
Revista clinica espanola,
K S Kendler, and
G R Heninger, and
R H Roth
May 1983,
Life sciences,
K S Kendler, and
G R Heninger, and
R H Roth
March 1988,
Psychiatry research,
K S Kendler, and
G R Heninger, and
R H Roth
November 1984,
Journal of neurochemistry,
K S Kendler, and
G R Heninger, and
R H Roth
August 1991,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
K S Kendler, and
G R Heninger, and
R H Roth
January 1991,
Journal of neural transmission. Parkinson's disease and dementia section,
K S Kendler, and
G R Heninger, and
R H Roth
February 1998,
Biological psychiatry,
