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The stimulation of gastric acid flow by thirty-six new pentagastrin analogs administered intravenously, intrajejunally and intrarectally was determined in rats. Some of the analogs are several times more active than the pentagastrin (Peptavlon, I.C.I.) used as control. Unlike the control, some analogs are absorbed in active form from the jejunum. The N-terminal substitution with alpha-aminooxy acids seems to increase the gastric secretory response, probably by improving the enzymatic resistance of the molecule to various enzymes. None of the analogs tested significantly inhibit the gastric acid output in rats induced by pentagastrin. Structure-activity relationships are discussed.
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
July 2010,
Bioorganic & medicinal chemistry letters,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
November 2013,
Molecules (Basel, Switzerland),
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
January 2014,
Mini reviews in medicinal chemistry,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
January 1986,
Proceedings of the Western Pharmacology Society,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
August 2000,
Toxicological sciences : an official journal of the Society of Toxicology,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
October 1997,
Journal of medicinal chemistry,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
January 1987,
Journal of cardiovascular pharmacology,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
November 1998,
Bone,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
August 2007,
Journal of peptide science : an official publication of the European Peptide Society,
I Schön, and
L Kisfaludy, and
J Náfrádi, and
L Varga, and
V Varró
August 1974,
FEBS letters,
