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Measles- or mumps virus-infected cells forming rosettes with lymphocytes from patients with multiple sclerosis. 1982

L H Tobler, and K P Johnson, and G Case Buehring

Peripheral blood lymphocytes (PBLs) from patients with multiple sclerosis (MS) were studied to determine the frequency at which they formed rosettes with target cells persistently infected with measles or mumps virus. Results were compared with (1) the rosette-forming capability of lymphocytes from age- and sex-matched normal control subjects and (2) the rosette-forming capability of lymphocytes with uninfected target cells from patients with MS. Comparison of mean measles antibody titers in patients with MS was significantly higher than in control subjects. A similar comparison for mumps antibodies showed a significant differences. There was no significant difference between patients and control subjects in the frequency of lymphocytes that formed rosettes, no matter which target cell was used. When data obtained using target cells infected with measles were analyzed according to sex or clinical classification, no significant difference was observed. Lymphocytes from patients or control subjects formed significantly more rosettes when reacted with virus-infected rather than uninfected target cells. These data suggest that PBL rosette formation with measles- or mumps-infected cells may represent nonspecific adherence rather than specific adherence.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297 Male Males
D008457 Measles A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM. Rubeola
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009107 Mumps An acute infectious disease caused by RUBULAVIRUS, spread by direct contact, airborne droplet nuclei, fomites contaminated by infectious saliva, and perhaps urine, and usually seen in children under the age of 15, although adults may also be affected. (From Dorland, 28th ed) Parotitis, Epidemic,Epidemic Parotitides,Epidemic Parotitis,Parotitides, Epidemic
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D005260 Female Females
D006385 Hemagglutination Inhibition Tests Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination. Hemagglutination Inhibition Test,Inhibition Test, Hemagglutination,Inhibition Tests, Hemagglutination,Test, Hemagglutination Inhibition,Tests, Hemagglutination Inhibition
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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