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Fifty-seven patients took part in a controlled double-blind trial between tiopronin and D-penicillamine as basic treatment for rheumatoid arthritis. Thirty-nine (19 receiving tiopronin, 20 receiving D-penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of the erythrocyte sedimentation rate, Ritchie index, and Lee index and in a sparing effect on symptomatic antiinflammatory therapy. Improvement in these variables was statistically highly significant at any interval with tiopronin, but was sometimes less or not at all significant with D-penicillamine. Nevertheless, the difference in effects between the 2 drugs never reached statistical significance. Six patients receiving tiopronin and 6 receiving D-penicillamine were taken out of the experiment because of side effects.
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
February 1973,
Lancet (London, England),
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
January 1998,
Clinical rheumatology,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
July 1973,
Annals of the rheumatic diseases,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
August 1979,
The Ohio State medical journal,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
February 1978,
Annals of the rheumatic diseases,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
January 1976,
Scandinavian journal of rheumatology,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
January 1986,
Indian journal of pediatrics,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
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M R Mazzoni, and
G Menegale, and
D Trippi
January 1979,
Harefuah,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
May 1983,
Arthritis and rheumatism,
G Pasero, and
P Pellegrini, and
U Ambanelli, and
M L Ciompi, and
V Colamussi, and
G Ferraccioli, and
P Barbieri, and
M R Mazzoni, and
G Menegale, and
D Trippi
December 1983,
Clinical rheumatology,
