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Two permanent cell lines, designated LU-65 and SK-Luci-6, were established from large-cell anaplastic lung cancers of two patients. Both cell lines grew as solid tumors in nude mice. The histologic pattern of the tumors in the nude mouse resembled that of the primary lung cancers in that the xeno-transplanted tissues showed no distinctive features indicative of cell type, a finding consistent with origin from a large-cell anaplastic lung cancer. Cells from both lines formed clones in semisolid agar. Flow cytometric analysis of SK-Luci-6 showed a hypertriploid stemline with a very high RNA-index. Line LU-65 had a hyperdiploid stemline evolving into a hypertriploid stemline with a high RNA-index. Chromosome analysis showed aneuploidy with abnormalities and marker chromosomes in both tumor cell lines. The isoenzyme pattern of LU-65 and Sk-Luci-6 indicated that they were of human origin and distinct from HeLa cells or another common contaminating line. Both cell lines released biologically active agents that could have caused the neutrophilia and hypercalcemia seen in the patients.
B Anger, and
R Bockman, and
M Andreeff, and
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S Jhanwar, and
T Kameya, and
P Saigo, and
W Wright, and
E J Beattie, and
H F Oettgen, and
L J Old
January 2002,
Anticancer research,
B Anger, and
R Bockman, and
M Andreeff, and
R Erlandson, and
S Jhanwar, and
T Kameya, and
P Saigo, and
W Wright, and
E J Beattie, and
H F Oettgen, and
L J Old
March 1985,
Cancer research,
B Anger, and
R Bockman, and
M Andreeff, and
R Erlandson, and
S Jhanwar, and
T Kameya, and
P Saigo, and
W Wright, and
E J Beattie, and
H F Oettgen, and
L J Old
February 1996,
Cancer genetics and cytogenetics,
B Anger, and
R Bockman, and
M Andreeff, and
R Erlandson, and
S Jhanwar, and
T Kameya, and
P Saigo, and
W Wright, and
E J Beattie, and
H F Oettgen, and
L J Old
January 1990,
Leukemia research,
B Anger, and
R Bockman, and
M Andreeff, and
R Erlandson, and
S Jhanwar, and
T Kameya, and
P Saigo, and
W Wright, and
E J Beattie, and
H F Oettgen, and
L J Old
June 1993,
Laboratory investigation; a journal of technical methods and pathology,
B Anger, and
R Bockman, and
M Andreeff, and
R Erlandson, and
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T Kameya, and
P Saigo, and
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E J Beattie, and
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L J Old
August 1990,
Journal of surgical oncology,
B Anger, and
R Bockman, and
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E J Beattie, and
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L J Old
July 1995,
International journal of cancer,
B Anger, and
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Experimental & molecular medicine,
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R Bockman, and
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August 1992,
International journal of cancer,
B Anger, and
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W Wright, and
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H F Oettgen, and
L J Old
January 1997,
Anticancer research,
