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We have studied the thyroid function of high-altitude-acclimated (6,900 m for 5 wk) and nonaltitude-acclimated control (198 m) rats. After 5 wk of high-altitude exposure the plasma concentrations of both thyroxine (T4) and triiodothyronine (T3) were lower than those in control rats (4.7 +/- 0.3 vs. 3.3 +/- 0.2 microgram/dl and 96 +/- 5 vs. 74 +/- 6 ng/dl, respectively). The plasma thyrotropin (TSH) concentration was elevated in the high-altitude-acclimated rats compared with controls (52 +/- 4 vs. 29 +/- 3 micrograms/dl, respectively). Gross anatomical (thyroid wt/body wt) and histological observations of thyroid tissue were consistent with elevated plasma TSH concentrations. These results suggest that the fall in the plasma concentrations of T4 and T3 during acclimation to severe hypoxia is due to a primary block of thyroid secretion and not to a fall in plasma TSH levels.
J M Connors, and
L G Martin
January 1981,
Progress in clinical and biological research,
J M Connors, and
L G Martin
March 1980,
The Journal of clinical endocrinology and metabolism,
J M Connors, and
L G Martin
January 1995,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
J M Connors, and
L G Martin
September 1976,
The Journal of clinical endocrinology and metabolism,
J M Connors, and
L G Martin
December 1976,
Clinical pharmacology and therapeutics,
J M Connors, and
L G Martin
May 1992,
The American journal of physiology,
J M Connors, and
L G Martin
October 1980,
Endocrinology,
J M Connors, and
L G Martin
August 1981,
Endocrinologia japonica,
J M Connors, and
L G Martin
March 1988,
Journal of endocrinological investigation,
J M Connors, and
L G Martin
October 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
