-transparent.png){kind=logo}
The clinical pharmacokinetics of amitriptyline were studied in four volunteers after the oral administration of 75 mg. Peak amitriptyline plasma concentrations ranged from 10.8 to 43.7 ng/ml. The disappearance was biphasic and followed first-order kinetics. The mean elimination half-life was 36.1 hours. The mean estimated first-pass metabolism of amitriptyline was 60 per cent. Significant quantities of the metabolite, nortriptyline, were produced although peak concentrations ranged from only 5.9 to 12.3 ng/ml. The relationship between these findings to clinical practice and earlier reports is discussed.
Related Publications
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
January 1981,
International journal of clinical pharmacology, therapy, and toxicology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
September 1964,
Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
January 1981,
Psychopharmacology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
January 1981,
Psychopharmacology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
September 1976,
European journal of clinical pharmacology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
January 1985,
Therapeutic drug monitoring,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
January 1979,
Progress in neuro-psychopharmacology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
April 2009,
Journal of pharmaceutical sciences,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
April 1986,
International clinical psychopharmacology,
V E Ziegler, and
J T Biggs, and
A B Ardekani, and
S H Rosen
December 1995,
Bulletin du cancer,
