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Two rapid, specific, and sensitive high-pressure liquid chromatographic (HPLC) assays were developed for cloxacillin in serum and urine. A reversed-phase column (RP-8) was selected for use with two different sets of HPLC conditions and sample pretreatment procedures. Cloxacillin extraction efficiencies are reported from serum and urine. Equations are presented for linear relationships between peak height or peak area ratios of cloxacillin to nafcillin (internal standard) and the cloxacillin concentration over a range of 0-80 micrograms/ml. The sensitivity limit of these assays was approximately 0.3 microgram/ml of a standard solution for one method and 0.05 microgram /ml for the other HPLC assay.
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
April 1988,
Journal of clinical pharmacy and therapeutics,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
May 1988,
Journal of chromatography,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
November 1984,
Journal of chromatographic science,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
November 1983,
Antimicrobial agents and chemotherapy,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
August 1986,
Antimicrobial agents and chemotherapy,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
July 1983,
Clinical chemistry,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
July 1976,
Analytical chemistry,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
November 1982,
Journal of pharmaceutical sciences,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
February 1982,
Chemical & pharmaceutical bulletin,
F W Teare, and
R H Kwan, and
M Spino, and
S M MacLeod
May 1984,
Antimicrobial agents and chemotherapy,
