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Thirteen patients with primary osteoporosis were treated for two years with sodium fluoride (NaF), calcium and dihydrotachysterol (group A). The dose of NaF was modified according to the serum fluoride concentration, which was kept as constant as possible between 0.20 and 0.25 microgram/ml. In patients with bone fluoride content greater than or equal to 0.20% a significant increase in the volumetric density and in the surface percentage covered with osteoid and with osteoblasts was observed. A second group of 7 patients with primary osteoporosis was also treated for 2 years with calcium and dihydrotachysterol, but without fluoride (group B). In these patients no significant change in the volumetric density or in the surface percentage covered with osteoid or osteoblasts was found. Patients in group A with a bone fluoride content less than 0.20% could not be distinguished from the patients in group B. Based on the available data an advice was given for the dosage of NaF in patients with osteoporosis. Regular assessment of the serum fluoride concentration remains advisable.
R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
January 1987,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
July 1981,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
October 1980,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
December 1971,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
July 1972,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
May 1977,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
July 1985,
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R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
January 2005,
Zeitschrift fur Orthopadie und ihre Grenzgebiete,
R G van Kesteren, and
S A Duursma, and
W J Visser, and
J van der Sluys Veer, and
O Backer Dirks
December 1986,
Ugeskrift for laeger,
