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Plasma HDL cholesterol (HDL-C) and major apolipoproteins, A-I (A-I) and A-II (A-II), and indices of hepatic microsomal function, liver cytochrome P-450 (P-450) and plasma antipyrine clearance rate (AP-CL), in eight alcohol consumers and eight non-drinkers were compared. Alcohol consumers had increased P-450 and AP-CL showing an induction of hepatic microsomal function, and elevated HDL-C, A-I and A-II as compared with values in non-drinkers. Liver cytochrome P-450 concentrations were directly proportional to plasma HDL-C (r = 0.732, p less than 0.01) and A-I (r = 0.564, p less than 0.05) levels. These data suggest that alcohol by inducing liver microsomal function increases plasma HDL and thus favorably alters one of the risk factors of coronary heart disease.
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
May 1988,
Pharmacology & toxicology,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
December 1979,
Clinical biochemistry,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
August 1973,
Anesthesiology,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
November 1980,
Canadian Medical Association journal,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
January 1986,
Alcoholism, clinical and experimental research,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
June 1986,
Polskie Archiwum Medycyny Wewnetrznej,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
April 2011,
The American journal of pathology,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
November 1975,
Biochemical pharmacology,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
July 1971,
Biochemical pharmacology,
P V Luoma, and
E A Sotaniemi, and
R O Pelkonen, and
C Ehnholm
May 1990,
Kardiologiia,
