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The efficiency of percutane isosorbide dinitrate (ISDN) therapy on 61 subjects with coronary heart diseases (angina pectoris, postinfarction state and myocardial insufficiency) was examined. Serum levels of ISDN in 12 subjects were measured gaschromatographically. The haemodynamic and clinical parameters received, as well as, the reduced attack-note of stenocardic symptoms demonstrate the therapeutic and prophylactic effectiveness of this kind of therapy. Sufficient systemic availability of ISDN in organism was evident. Non of these subjects seem to develop a tolerance, because stenocardic symptoms were not obvious. No diminished sensitivity to acute acting nitrates was present. Intervals in long-term therapy with nitrates are discussed. "Isoket ointment" comes in premeasured doses and is easy to apply. Good patient compliance is obtained.
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