-transparent.png){kind=logo}
The magnitude and duration of elevated plasma progesterone levels resulting from subdermal implantation of progesterone pellets were investigated in full nursing women. This condition was chosen because it is associated with a low rate of ovulation and minimal endogenous progesterone production. In addition, treatment with progesterone pellets was intended to be a substitute for oral or parenteral administration of synthetic progestogens to nursing mothers. A control group of full nursing women receiving no hormones provided blood samples so that basal plasma progesterone levels from the second to the sixth post-partum month could be assessed. Progesterone pellets were implanted subdermally on day 30-35 after delivery. Insertion of 2, 4 or 6 pellets each containing 100 mg of progesterone caused an initial elevation of plasma progesterone to 5.9, 9.9 and 13.5 nmol/l, respectively. This initial elevation was followed by a gradual decline, so that basal levels were attained at 70, 100 and 150 days after insertion of 2, 4 or 6 pellets. Implantation of 6 progesterone pellets led to a significant decrease in the ovulation rate of nursing women. These results indicate that subdermal implantation of 6 progesterone pellets can provide biologically effective levels of the hormone for up to 5 months.
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
June 1958,
The Yale journal of biology and medicine,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
November 1983,
Chemical & pharmaceutical bulletin,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
October 1974,
The Journal of endocrinology,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
July 1974,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
April 1982,
Ginecologia y obstetricia de Mexico,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
June 1946,
Anais brasileiros de ginecologia,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
April 1971,
Nordisk medicin,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
February 1976,
Experientia,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
January 1998,
Acta veterinaria Scandinavica,
H B Croxatto, and
S Díaz, and
O Peralta, and
A M Salvatierra, and
A Brandeis
February 1974,
Theriogenology,
