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The distribution of iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.
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