Biomaterial Database

Clinical trial of met-enkephalin analogue (DAMME, FK 33-824) on heroin abusers. 1982

H L Wen

Twenty cases of hard-core heroin abusers were treated by detoxification with DAMME (Sandoz FK 33-824). It was found that 55% (n = 11) were detoxified in seven days and were satisfied with analogue. The abstinence period, during post-treatment follow-up, varied from two days to six months. The withdrawal syndrome scoring was significant in this group but not in the failure group (45% (n = 9)). No sign of tolerance to DAMME was noted in this series.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004744	Enkephalin, Methionine	One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	Methionine Enkephalin,5-Methionine Enkephalin,Met(5)-Enkephalin,Met-Enkephalin,5 Methionine Enkephalin,Enkephalin, 5-Methionine,Met Enkephalin
D005260	Female		Females
D005405	D-Ala(2),MePhe(4),Met(0)-ol-enkephalin	A stable synthetic analog of methionine enkephalin (ENKEPHALIN, METHIONINE). Actions are similar to those of methionine enkephalin. Its effects can be reversed by narcotic antagonists such as naloxone.	DAMME,FK 33-824,FK-33-824,FK-33824,Tyr-Ala-Gly-MePhe-Met-OH,FK 33 824,FK 33824,FK33824,Tyr Ala Gly MePhe Met OH
D006556	Heroin Dependence	Strong dependence or addiction, both physiological and emotional, upon HEROIN.	Heroin Abuse,Heroin Addiction,Heroin Smoking,Abuse, Heroin,Addiction, Heroin,Dependence, Heroin,Heroin Smokings,Smoking, Heroin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man