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The effect of a kaolin--pectin suspension on the bioavailability of orally administered digoxin was evaluated when both drugs were given concomitantly and when their time of administration was separated by 2 hr. Coadministration of the antidiarrheal with the cardiac glycoside delayed absorption of the latter and, at the same time, decreased by 62% the amount of drug absorbed. Intersubject variation in digoxin bioavailability also was increased more than twofold. When the kaolin--pectin suspension was given 2 hr before the cardiac glycoside, the digoxin absorption rate was not affected, although its relative extent of absorption was reduced by about 20%. In contrast, when the antidiarrheal was given 2 hr after digoxin, neither the rate nor the extent of absorption of the cardiac glycoside was perturbed. No change in the intersubject variability in digoxin bioavailability was noted whether the antidiarrheal was given 2 hr before or 2 hr after the cardiac glycoside.
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
October 1981,
Journal of clinical pharmacology,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
June 1987,
International journal of clinical pharmacology, therapy, and toxicology,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
November 1976,
The New England journal of medicine,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
April 1983,
Research communications in chemical pathology and pharmacology,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
March 1968,
Journal of pharmaceutical sciences,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
January 1981,
Journal of clinical pharmacology,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
March 1991,
Oral surgery, oral medicine, and oral pathology,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
October 1991,
Annals of internal medicine,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
January 1984,
International journal of clinical pharmacology research,
K S Albert, and
J W Ayres, and
A R DiSanto, and
D J Weidler, and
E Sakmar, and
M R Hallmark, and
R G Stoll, and
K A DeSante, and
J G Wagner
November 1978,
Lancet (London, England),
