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One hundred and seventy six patients (81 controls, 95 receiving treatment) have entered a prospective randomized trial of long-term oral adjuvant razoxane (ICRF-159) following removal of a colorectal cancer. The median follow-up is 34 months. The treated patients in Dukes' groups B and C have a significantly longer disease-free interval than the control patients (P = 0.01 'as randomized' and P = 0.004 'as treated'). The differences in survival for Dukes' groups B and C are not significant, although follow-up is short. In Dukes' groups B and C, however, 24 of 56 of the patients in the control group have died (43%), as against only 17 of 64 in the treatment group (27%). The treatment produces very few side-effects, is well tolerated by patients, and is taken orally.
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
January 1983,
Cancer chemotherapy and pharmacology,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
August 1984,
The British journal of surgery,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
December 1976,
Lancet (London, England),
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
January 1978,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
March 1980,
The British journal of dermatology,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
January 1978,
International journal of radiation oncology, biology, physics,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
September 1979,
Cancer,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
November 1985,
British journal of cancer,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
January 1984,
Clinical & experimental metastasis,
J M Gilbert, and
K Hellmann, and
M Evans, and
P G Cassell, and
B Stoodley, and
H Ellis, and
C Wastell
June 1976,
Cancer treatment reviews,
